Role of genetic modifiers in an orthologous rat model of ARPKD
نویسندگان
چکیده
منابع مشابه
Role of genetic modifiers in an orthologous rat model of ARPKD.
Human data and animal models of autosomal recessive polycystic kidney disease (ARPKD) suggest that genetic factors modulate the onset and severity of the disease. We report here for the first time that ARPKD susceptibility is attenuated by introgressing the mutated Pkhd1 disease allele from the polycystic kidney (PCK) rat onto the FHH (Fawn-Hooded Hypertensive) genetic background. Compared with...
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Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD.
20-Hydroxyeicosatetraenoic acid (20-HETE) has been implicated as a potential mediator in epithelial cell proliferation and cyst formation in polycystic kidney disease (PKD). In the present study, we studied the effects of chronic blockade of 20-HETE synthesis in an orthologous rodent model of autosomal recessive polycystic kidney disease (ARPKD), the PCK rat. RT-PCR analysis indicated that the ...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2012
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.00187.2011